Predictions:

Good VS Bad: Lacus Clyne Faction VS Gilbert Dullindal

Djibril will die soon. Shinn will defect to the Clyne faction after realizing that it wasn't Kira's fault that Stellar died and so on. Shinn will accept Cagalli. Luna will die by the hands of Rey, and this will trigger Shinn's defection as I wrote about in the sentence before this. Gilbert & Rey will be the final badguys. The upcoming DOM troopers will also die of course. Kira will fight Shinn before Shinn defects. Athrun will fight with Rey, but the final gundam duel will be between Shinn & Rey.

This only leaves one big question: Who the fuck will Kira, Cagalli & Athrun fight with their new spankin' mobile suits?

Oh and Yzak/Dearka will probably get owned by Kira as usual and then just fade out of the show.
It's like they don't exist anymore in the eyes of the dumbass script crew.