Akatsuki is probably the "ultimate evil" in Naruto, right? And seeing how and what the manga is doing right now with Team 7 fighting Akatsuki members, my guess is that they'll beat them 2 at a time, until all members are defeated. Then I bet there's going to be a Sannin fight again where Orochimaru actually gets killed and then probably Naruto and Sasuke fighting in thet last fight ever in Naruto.

What are your guesses on how the series will end?