Originally posted by: darkmetal505
It could, but I dont think it will happen. The sharingan probably took many generations to develop anyway.
Quoted for the truth.

And the guy posting about strong people without bloodlines, you forgot Lee!

And I'm pretty sure Sai doesn't have a bloodline.

Others: Tsunade, the Aburame clan, Kibas clan, ZABUZA!, I can go on....

P.S. I don't think orochimaru could just make a powerful clone of Itachi unless Itachi was dead and he used the revival jutsu he used on the dead hokages.