I only ran into one program (Peer Guardian) that didn't support vista. Only took me a minute or 2 to find and dl vista drivers for my video card. and Counterstrike : Source worked just fine, maybe better than if i were running XP even though it made me 'run as admin' to open steam. Also, found that the klite codec pack i use w \ media player classic works fine. i love the layout though, im using the quick launch area for all the programs i run + my computer and its a nice clean layout.