Jiraiya will die by Pein's hand. Kakashi, a long-time member of Root, will become Hokage by killing Tsunade. He will do so with the MS he gained when he killed Rin, his last friend, while training for Root. (Best plot twist ever, by the way)

Sasuke and Itachi will face each other, Sasuke will win. Tobi will show up and beat Sasuke. He'll reveal the true purpose of the Sharingan -- to control the Bijou using a Sharingan technique. It will also be revealed that Uchiha Madara was messing around with the Kyuubi the night Naruto was born, and that the Kyuubi got loose. They'll kill the rest of Akatsuki.

Naruto will be pissed at Kakashi. Kakashi won't care, but he'll still think Akatsuki is a threat to Konoha. Kakashi and Naruto will work together again, but will face whats left of the Uchiha clan. Kakashi will kill Tobi. Sasuke will kill Kakashi as revenge for killing the last member of his family. Naruto will kill Sasuke for being a whiny bitch.

The end. It'll be done in 100 chapters.

Love,
Kishi