Well, Tsunade's death is going to be Sakura's inspiration, not Naruto's. If Tsunade dies, it will be for Sakura to develop as a character. Naruto's peak is with Jiraiya's death (unless Kakashi or Iruka dies).

Not saying that Tsunade won't die while Naruto is away, but if she does, it won't be to fuel Naruto's fire.