That's what a bit of nicely managed CG can do. And I think this is just the begining of that technical trend. For now, if you watch the details, you get the CG feeling and understand the technical choices that had to be made for the ep to be produced quickly enough without impacting production costs too much.
Also they had to make some choices so that it remaines anime and keeps an artistic touch.
I'm still wondering wether it's a good or a bad thing. Time will tell I guess. It also really depends on the quality of the scenario and story.
I remember the first CG anime (french or other ones) that were just horrible for lack of story or anything interresting. Then you have some hilarious eps from "Tripping the Rift" were quality isn't even a problem, since humor, sarcasm and everything about it is way more important.

Regarding american voices, they're a bit too clean, studio recorded with absolutely no sound scene integration. So it really sounds like some video games. But it's fine too, at least they improved that part.

Regarding the story:
Is he some kind of clone or artificially grown human?
They talk as if he'd be eliminated, but he wasn't. His brainwashing did not affect his abilities. For some reason, the girl is either the target of part of it.

Other than that, I do not think of anything particular, strange start I'd say.