I usually run magic pen red/quint and mp5 yellow/blue on ryze. The most effective way of building him for me to to rush catalyst and then get sorc shoes. From there i either finish banshee or build Frozen Heart depending on the opponent. I'll build a tear after catalyst if i'm getting fed, otherwise i find that building a tear early makes you too fragile. Typical build would be something like sorc, banshee, frozen heart, void staff, archangel and Guardian Angel last.