Finished it!

Not everything turned out the way I wanted, and I certainly didn't do everything, but I beat it with the, "Wild Card / No God, No Masters" ending on Hardcore. 37 hours, level 27, mostly sneaker/sniper with constantly improving Speech toward the end. I favored pistols most of the game, until I got the sniper rifle and anti-material rifle.

Excellent game. Time to start all over, maybe work a few of the kinks out. Eventually I'm going to try for a pacifist run, Fallout 1/2 style.