It's been many times now that Karin was saying "Sasuke's chakra is different", "He's become so cold" etc.

With his "emotionless face" before running through both Danzou and Karin we can assume he cares solely about reaching his goals and Karin was expendable, ergo. If he treated her as tool, he could get another one.

Question is, will he? Personally, I think not because he didn't even ask about Suigetsu and Juugo.