Yeah, indeed. Better wait till all three royal guards are out, and maybe even the king. Only then it will be worth it to attack. Bards will still sing of their heroics 100 years later.
Assuming Neferpitou could jump high enough to take bombers down (without knowing what they are and why they are there), why not? The hunters could sneak in to slay the Queen while Neferpitou's jumping up and down. Or they could just use rockets to deliver the poison.
But this is just silly talk. Obviously each and every ant needs to be beaten to death by hand in a shounen show. I admit it would be a highly anticlimactic ending for this arc if they used insecticides.