Well, I might have forgotten a few bosses, but before this it was at least possible to imagine the enemies could do something to hurt them and/or some of the crew were already quite compromised, like during Nami's arc where Luffy nearly had to learn how to breath water and Zoro was half-dead already after shaking hands with Mihawk. Now it seems very unlikely indeed with Hody ready to piss his pants and his lieutenants simply too stupid to realise they don't have even a cotton candy's chance in Chopper's hand.