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Plague, and the strong one.
On paper the contermeasures work, in reality we know it doesn't in an ever working society. COVID is a strong ongoing warning that should an epidemic as lethal as that plague (or last century influenza) happen again, we will struggle, a lot.
I wonder how that arc will unfold. Even with godlike powers.

Then a counterbalance evil appears. A good show needs a good evil character. Too bad it feels like that one is caricatural as f... They told us he was a genius. I hope that will prove useful to the story.