Just as a third voice, I've never played the game, refuse to play the game (tower defense not my thing), but overall, I think the show has promise.

It is teetering on the latter side of the line that demarks "Just for Fans" and "Good for cold viewers of a franchise."

They're handling the exposition very nicely. You can sorta tell where a lesser studio would be pulling right from the IP and dropping an info-dump to the player, but at least so far, they've integrated it nicely with other character's dialogue or even the no-name guy complaining.

The grim, but almost clean/Brutalist atmosphere is something relatively uncommon, and I do enjoy the vibe of the town setting thus far.

The enticing mystery and hook to the series is why the Doctor was in a sarcophagus in the middle of a hostile city for however long(?) while the others, all relatively young, have a long history with them.

The character designs are good too, like Amiya being a bunny girl without being the very anime-kind of bunny girl, and I assume the knight is a horse person because of course she would be, in the vein of monstergirl centaurs who are always knights and I like that trope.

The downside is very obviously the villains. Flat out, Mephisto is a completely shit character. The others make sense, you have a very angry population of tormented Infected who lose control, do horrible things that most rioters and rebellions do, especially when they're backed by either powerful or charismatic(?) leader like this Talulah (presume dragonewt monster girl?), or the Crownslayer girl who is after some info. But Mephisto undermines everything they're doing, is a cardboard flat "crazed guy" and the other normal footsoldiers have absolutely zero incentive to follow him or his orders. He's the kind of character who gets killed in their sleep by their compatriots because the illogical behavior will only cause them to lose. Never actually threatening in any way despite what the series attempts to portray. Just annoying.

So maybe Talulah fixes the villains angle of the series, but overall, doesn't she still have the incentive to let them go?

I guess everyone wants The Doctor real bad for their own reasons, and only Rhodes Island has an altruistic one. Their rescue operation is fucked at this point. I assume they're going to have to lose nearly everyone shown so far to get out of this.