</div><table border='0' align='center' width='95%' cellpadding='3' cellspacing='1'><tr><td>QUOTE (TwisT &#064; Jan 4 2004, 12:13 AM)</td></tr><tr><td id='QUOTE'> Well i maybe got this wrong but isnt Tsunades little brother The 4th Hokage?? And he is dead.. </td></tr></table><div class='postcolor'>
Tsunade&#39;s brother and the fourth are completely different people.

It&#39;s been a while since I read the manga, but I think the connection is that Tsunade, Orochimaru and Jiraiya were teammates taught by the 3rd. Jiraiya went on to become the teacher of the 4th, who went on to teach Kakashi who is now teaching Naruto. Do correct me if I messed up somewhere in there.