I wonder if the anime people got pissed when they saw this topic. For all they know he is about to get killed now.

I think that eventually it soing to be Jiraiya or Tsunade killing Orochimaru. They would have to work together to do it, but it is possible.

Perhaps if Orochimaru was somehow behind the slaughter of the Uchiha Clan (he coaxed Itachi into measuring himself, etc..) then Sasuke might do it.