To answer this is necessary to know if Itachi killed all his family before or after the sealing of the kyuubi.
If it was before, we will never know until they show it on the store.
If it was after, he can't. If any of his clan was alive, we can easily assume that:
a. Somebody from his clan, or even Itachi himself when he still was on the good side, knew how to do the mange sharingan.
b. If any member of the Uchiha clan was alive, he/she would be fighting for Konoha.
c. They'd have used the mange sharingan against the kyuubi.
d. If they used the mange sharingan against the kyuubi, it didn't work.

Therefore, if any of the Uchiha clan was alive, except by Sasuke who doesn't know how to do mange sharingan, probably it would have been used in the fight against the kyuubi, and it didn't work. And if it didn't work then, the hypothesis that it will work against the kyuubi is not based on reality.
Since I don't know when the Uchiha clan was wipped out of the face of the earth, except for Sasuke, I don't have data enough to make any assumption of this kind. And if it wasn't stated in the story, nobody has.