Characters that don't have anything to add to the plot. Iruka is a nice guy but he already fulfilled his purpose. Same thing for Konohamaru. Not die but perhaps go to the Sand to be an exchange student or something. He has too much to grow up still, and there is no time for that in the story. Iruka doesn't seem that he will be an exceptional ninja in the future. His function was to be a father/supportive figure for Naruto for the first time. Naruto is pretty self-confident now and doesn't need that figure in his life, anymore.
Now, IMO one thing that is complicating this plot is the fact that there are three main bad guys: Itachi, Oro and Sasky. IMO, it totally de-centralizes the story, and may lead to a lot of confusion in the future.
Who should Naruto go after first? For me, as much as some guys here love Itachi, he still haven't a cleary established function in the story. Is he there to give Sasuke's existence a purpose? Is he there to be Naruto's #1 enemy? But that function wouldn't be of the now evil Sasuke or even Oro, since likely, he still wants revenge against Konoha and certainly Naruto will defend the village ? And the kyuuby thing....what are they going to do? Dissect Naruto to extract the fox from him? Just doesn't sound very likely that it's an attainable goal. Since Itachi likes bells, I thought of the story of the rats deciding to put a bell in the cat's neck. Oro's goal of destroying Konoha seemed way more feasible in comparsion. No matter what you think, the kyuuby is stronger than Itachi. So either you face Naruto with the kyuuby and you will lose, being you Itachi whoemver, or you get hold of Naruto and unseal the kyuubi, and likely the kyuubi will do you right away. Itachi is *not* the 4th.
Anyway, two very difficult things to accomplish.
Then, as if those three weren't enough, we have the 6 remaining members of the Akatsuki yet to be introduced...
Given the fact that Sasuke is an ass, that's way enough reason to make him Naruto's enemy, I don't see the need of adding have Oro or Itachi to the story. Sasuke is kinda like a weak Kisame. Fishface is an ass, and Akatsuki or non Akasuki, he'd be killing people for pleasure and profit the exact same way. Sasuka is an ass and brother or non brother, he'd still be a lazy and envious idiot, trying to beat Naruto or even kill him just because his pride was hurt.
I'd say one of those three should die, or even two of them, in order to establish priorities in the narrative. Right now, we're wasting a lot of time with the waste of time that's Sasuke. Let's kill the remaining Sound ninjas, kill or beat Sasuke into a shapeless pulp and go on with the story, wherever it may go.