the pilot chapter could probably indicate to you that Naruto's mother (and family, on a general notice), will not play any significent part in the story...

sure, Kishimoto might decide to go with the popular 'Naruto is the 4th's son' thing, or with the less popular but far more fun 'Naruto's mother is the leader of Akatsuki' theory, but as the story began, they weren't meant to play a grand part of it or to have any serious effect. the more 'important' families seem to be the idiotic Uchiha dudes and the random bad guy childhood trumatic one's...